Mutation that makes toxic protein responsible for cardiac aging in patients with rare aging disease

Children with progeria, a rare disorder that causes premature aging, die in their teens of ailments that are common in octogenarians: heart failure and stroke. Kan Cao, a University of Maryland assistant professor of cell biology and molecular genetics, urgently wants to help find a cure. Cao and her colleagues have taken a big step in that direction, showing that a toxic protein destroys muscle cells inside the patients’ arteries. The researchers suspect the damaged arteries are more prone to failure.

Until now, researchers didn’t know what mechanism may be causing the patients’ deaths. They knew a genetic mutation makes patients’ cells produce progerin, a toxic form of a protein that, in healthy people, forms the skeletal structure of cell nuclei. In previous studies Cao and others found that progerin builds up in cells of elderly people, suggesting that it is also linked to normal aging. But progerin’s effects on cells were unknown before this study.

Read the full, original story: Racing the Clock to Help Young Patients with Old Hearts

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