Genome studies reveal roots of TB drug resistance

Nature TB
Image via Nature. Credit: Andrew Aitchison/IN Pictures/Corbis

It is never a good time to come down with tuberculosis, but in recent years the outlook has become worse. Resistant strains of tuberculosis are on the rise.

Now, two teams of scientists have published large catalogues of the mutations that confer resistance on M. tuberculosis after sequencing the complete genomes of hundreds of samples. Their studies greatly increase our understanding of the ways in which this long-term nemesis evades our most potent drugs. Additionally, physicians can use the more complete list of resistance mutations to avoid giving patients drugs that will not help them, while quickly prescribing more appropriate treatments.

Read the full, original story here: Genomes reveal roots of TB drug resistance

Additional Resources:

  • TB genomes yield insights on drug resistance,” SciDev.Net
    This article includes the results of an additional study, not published in Nature Genetics (and not included in their article). This study, by researchers at the Center for Public Health Research in Valencia, Spain, “looks at how the bacterium accompanied ancient human migration out of Africa and multiplied with increases in human population densities.”
  • How TB evolves to get the better of humans,” Medical News Today
    Another recent study, conducted by researchers at Stanford University and published in PLoS, described how the tuberculosis bacterium uses natural selection to adapt and perfect itself.
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