Not the end of men: Set of Y chromosome conserved through evolution

A core set of genes on the Y chromosome has been retained through much of animal evolution, not just for male sexual development, but also as regulatory genes in a wide array of tissues, according to two studies published April 23 in Nature. Previous research has shown that the Y chromosome has undergone dramatic gene loss, retaining only 3 percent of its ancestral genes, compared to 98 percent for the X chromosome. Two independent teams—one led by David Page at MIT, the other by Henrik Kaessmann and Diego Cortez at the University of Lausanne in Switzerland—studied a wide variety of animals to demonstrate that the Y chromosome eventually developed a stable set of genes.

The papers provide “a tremendous rational for why these genes have been retained,” said geneticist Carlos Bustamante of Stanford Medical School, who was not involved in the work. “This massacre of genes, as it were, is really tempered by the genes that have been retained, [which] have been retained for a very specific reason. It’s not a random subset of genes.”

Read the full, original story: The Surprising Evolution of Sex Determiniation

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